DPP4 monoclonal antibody, clone TP1/19
产品名称： DPP4 monoclonal antibody, clone TP1/19
英文名称： DPP4 monoclonal antibody, clone TP1/19
产品编号： MAB4975
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native DPP4.
- Immunogen:
- Native purified DPP4 from human peripheral blood lymphocytes.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- The monoclonal antibody is directed against the CD26- antigen, which is expressed on human activated T- and B- cells. CD26 is required for T cell proliferation. It is expressed on 10-60% of resting T cells in normal peripheral blood. There is a selective decrease of CD4+ CD26+ T cells in HIV-1 infected individuals. Reacts with the 110KDa T cell activation antigen that has cell surface dipeptidyl peptidase Iv (DPPIV) enzyme activity. The CD26 antigen is a functional collagen receptor as well as a DPPIV ectoenzyme which cleaves amino-terminal dipeptides with either L-proline or L-alanine at the penultimate position. CD26 (also known as dipeptidyl peptidase IV (DPP IV), adenosine deaminase (ADA) binding protein) is an atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and is upregulated during T cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a
- Form:
- Liquid
- Isotype:
- IgG2b
- Storage Buffer:
- In buffer containing 1% BSA, pH 7.2 (0.09% sodium azide)
- Storage Instruction:
- Store in the dark at 4°C. Avoid prolonged exposure to light.
- Recommend Usage:
- Flow Cytometry (20 ul/106 cells)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Direct association of adenosine deaminase with a T cell activation antigen, CD26.
Kameoka J, Tanaka T, Nojima Y, Schlossman SF, Morimoto C.Science. 1993 Jul 23;261(5120):466-9.
- 2.
- Human CD4 helper T cell activation: functional involvement of two distinct collagen receptors, 1F7 and VLA integrin family.
Dang NH, Torimoto Y, Schlossman SF, Morimoto C.J Exp Med. 1990 Aug 1;172(2):649-52.
- 3.
- Interleukin 2 production by human T lymphocytes identified by antibodies to dipeptidyl peptidase IV.
Scholz W, Mentlein R, Heymann E, Feller AC, Ulmer AJ, Flad HD.Cell Immunol. 1985 Jun;93(1):199-211.
- Entrez GeneID:
- 1803
- Gene Name:
- DPP4
- Gene Alias:
- ADABP,ADCP2,CD26,DPPIV,TP103
- Gene Description:
- dipeptidyl-peptidase 4
- Omim ID:
- 102720
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq
- Other Designations:
- T-cell activation antigen CD26,adenosine deaminase complexing protein 2,dipeptidylpeptidase 4,dipeptidylpeptidase IV,dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)