Anti-AKT1 Polyclonal Antibody-抗体-抗体-生物在线
北京索莱宝科技有限公司
Anti-AKT1 Polyclonal Antibody

Anti-AKT1 Polyclonal Antibody

商家询价

产品名称: Anti-AKT1 Polyclonal Antibody

英文名称: AKT 1;AKT;AKT1;AKT-1;AKT1_HUMAN;C AKT;cAKT;MGC9965;MGC99656;Oncogene AKT1;PKB;PKB alpha;PKB-ALPHA;PRKBA;Protein Kinase B Alpha

产品编号: K009699P

产品价格: null

产品产地: 北京

品牌商标:

更新时间: 2025-01-17T10:18:30

使用范围: WB ELISA IHC-P IHC-F Flow-Cyt ICC IF

北京索莱宝科技有限公司
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The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.