FITC标记的白细胞介素增强子结合因子2抗体
产品名称： FITC标记的白细胞介素增强子结合因子2抗体
英文名称： Anti-ILF2/FITC
产品编号： HZ-16603R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ILF2/FITC Conjugated antibody
FITC标记的白细胞介素增强子结合因子2抗体
| 英文名称 | Anti-ILF2/FITC |
| 中文名称 | FITC标记的白细胞介素增强子结合因子2抗体 |
| 别 名 | HGNC:6037; ILF 2; ilf2; ILF2_HUMAN; Interleukin enhancer binding factor 2; Interleukin enhancer binding factor 2, 45kDa; Interleukin enhancer-binding factor 2; MGC8391; NF 45; NF45; Nuclear factor of activated T cells 45 kDa; Nuclear factor of activated T-cells 45 kDa; PRO3063. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ILF2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is the 45 kDa component of nuclear factor of activated T-cells (NFAT), a heterodimer of 45 kDa and 90 kDa proteins. NFAT is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The complex has been shown to repair DNA breaks by nonhomologous end joining and can also negatively regulate the microRNA processing pathway. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Jun 2012] Function: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Subcellular Location: Nucleus > nucleolus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 DZF domain. Database links: Entrez Gene: 3608 Human Entrez Gene: 67781 Mouse Entrez Gene: 310612 Rat Omim: 603181 Human SwissProt: Q12905 Human SwissProt: Q9CXY6 Mouse SwissProt: Q7TP98 Rat Unigene: 75117 Human Unigene: 227258 Mouse Unigene: 137428 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
该基因编码的蛋白是活化T细胞核因子（NFAT），分子量为45 kDa的组成的异源二聚体的分子量为45 kDa和90 kDa蛋白。NFAT是白细胞介素2基因T细胞表达所必需的转录因子。它还结合RNA，是乙型肝炎病毒聚合酶的包封和蛋白启动的基本组成部分。复杂的已被证明的非同源末端连接修复DNA断裂，也可以负调控miRNA的加工途径。选择性剪接导致多个转录变体。在3号染色体和14号染色体上发现了相关的假基因。[ RefSeq 2012军提供]