产品简介
英文名称
Anti-MAPK8/10 Polyclonal Antibody
宿主
Rabbit
别名
MAPK8;JNK;JNK-46;JNK1;JNK1A2;JNK21B1/2;PRKM8;SAPK1;SAPK1c;JNK3;JNK3A;PRKM10;SAPK1b;p493F12;p54bSAPK;MAPK10
靶标
MAPK8/10
稀释比例
WB 1:1000-3000. IHC 1:100-300.
蛋白分子量
35/44/48/49/53kDa
Gene ID
5599/5602
保存
Store at -20°C. Avoid freeze / thaw cycles.
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法
Affinity purification
亚型
IgG
免疫原
A synthetic peptide of Human MAPK8/10
亚细胞定位
Cytoplasm
Swiss Prot
P45983/P53779
背景资料
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Public Immunogen Range
320-370/427aa
克隆类型
Polyclonal Antibody
交叉反应
Human Rat Mouse
应用
IHC WB
规格
50ul 100ul
 
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图
Immunohistochemistry of paraffin-embedded Human stomach cancer with MAPK8/9/10 antibody diluted at 1:200
Western blot analysis with MAPK8/9/10 antibody diluted at 1:2000;Lane:Mouse liver,Mouse kidney