Fasciculation and elongation protein zeta-2 (FEZ2) is a homolog to the mammalian FEZ1, itself an ortholog of the C. elegans UNC-76.  In contrast to FEZ1, FEZ2 mRNA is widely expressed in mouse tissues.  FEZ2 interacts with protein kinase C (PKC)-zeta substrate and induces neurite extension of PC12 cells when co-expressed with a constitutively active form of PKC-zeta, suggesting FEZ2 may play an important role in the morphological changes of various cells by associating with PKC-zeta in a tissue non-specific manner.  FEZ2 can interact with FEZ1 through its c-terminal regions and especially its coiled-coil region.  At least two isoforms of FEZ2 are known to exist.