UCHL1 polyclonal antibody
产品名称： UCHL1 polyclonal antibody
英文名称： UCHL1 polyclonal antibody
产品编号： PAB12509
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against full length recombinant UCHL1.
- Immunogen:
- Recombinant protein corresponding to full length human UCHL1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Storage Buffer:
- In antiserum (10 mM sodium azide)
- Storage Instruction:
- Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
- Recommend Usage:
- Immunofluorescence (1:500-1:1000)
Western Blot (1:2000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.
Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr.Cell. 2002 Oct 18;111(2):209-18.
- 2.
- Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia.
Kurihara LJ, Kikuchi T, Wada K, Tilghman SM.Hum Mol Genet. 2001 Sep 1;10(18):1963-70.
- 3.
- The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase.
Wilkinson KD, Lee KM, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J.Science. 1989 Nov 3;246(4930):670-3.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of whole bovine brain extract stained with UCHL1 polyclonal antibody (Cat # PAB12509) showing a strong and clean band at about 24kDa.
- Immunofluorescence
- Shows rat mixed neuron/glial cultures stained with UCHL1 polyclonal antibody (Cat # PAB12509) (green). Blue is a DNA stain. Note that the UCHL1 stains neurons strongly and specifically, and that the staining is concentrated in the cell bodies, though some does extend into the dendrites also.
- Entrez GeneID:
- 7345
- Gene Name:
- UCHL1
- Gene Alias:
- PARK5,PGP9.5,Uch-L1
- Gene Description:
- ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease
- Other Designations:
- ubiquitin C-terminal esterase L1,ubiquitin carboxyl-terminal esterase L1,ubiquitin thiolesterase L1
- Gene Pathway