AGT monoclonal antibody (M01), clone 1A10
产品名称: AGT monoclonal antibody (M01), clone 1A10
英文名称: AGT monoclonal antibody (M01), clone 1A10
产品编号: H00000183-M01
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant AGT.
- Immunogen:
- AGT (AAH11519, 376 a.a. ~ 485 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- TIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANPLSTA
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG1 lambda
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.73 KDa) .
- MSDS:
- Download
- Publication Reference
- 1.
- A haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice as compared to -217G.
Jain S, Vinukonda G, Fiering SN, Kumar A.Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1849-57. Epub 2008 Oct 22.
- 2.
- HNF-1 alpha plays an important role in IL-6 induced expression of the Human Angiotensinogen Gene.
Jain S, Li Y, Patil S, Kumar A.Am J Physiol Cell Physiol. 2007 Jul;293(1):C401-10. Epub 2007 May 2.
- Applications
- Western Blot (Cell lysate)
- AGT monoclonal antibody (M01), clone 1A10 Western Blot analysis of AGT expression in HepG2 ( Cat # L019V1 ).
- Protocol Download
- Western Blot (Transfected lysate)
- Western Blot analysis of AGT expression in transfected 293T cell line by AGT monoclonal antibody (M01), clone 1A10.
Lane 1: AGT transfected lysate(53 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged AGT is approximately 1ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 183
- GeneBank Accession#:
- BC011519
- Protein Accession#:
- AAH11519
- Gene Name:
- AGT
- Gene Alias:
- ANHU,FLJ92595,FLJ97926,SERPINA8
- Gene Description:
- angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq
- Other Designations:
- OTTHUMP00000035878,alpha-1 antiproteinase, antitrypsin,angiotensin I,angiotensin II,angiotensinogen,pre-angiotensinogen,serine (or cysteine) proteinase inhibitor
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