Description

The salivary gland produces enzyme-containing saliva to lubricate the oral cavity and assist with digestion. It consists of three pairs of major salivary glands and many minor ones in the oral cavity [1]. Histology studies show that the salivary gland is a compound tubuloalveolar gland, surrounded by connective tissue to further divide the gland into lobes and lobules. The secretory end pieces consist of a spherical mass of cells called acinus. Mouse salivary gland fibroblasts (MSGF) are embryonic mesoderm derived mesenchymal cells and they are responsible for synthesis of extracellular matrix such as type I and/or type III collagen [2]. MSGF are very versatile and provide a useful tool for studying collagenous fibroma and oral neoplasms [3].

 

MSGF from ScienCell Research Laboratories are isolated from postnatal day 2 C57BL/6 mouse salivary gland. MSGF are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. MSGF are characterized by immunofluorescence with antibodies specific to fibronectin. MSGF are negative for mycoplasma, bacteria, yeast, and fungi. MSGF are guaranteed to further expand for 5 population doublings under the conditions provided by ScienCell Research Laboratories.

 

Recommended Medium

It is recommended to use Fibroblast Medium (FM, Cat. #2301) for the culturing of MSGF in vitro.

 

Product Use

MSGF are for research use only. They are not approved for human or animal use, or for application in in vitro diagnostic procedures.

 

Storage

Upon receiving, directly and immediately transfer the cells from dry ice to liquid nitrogen and keep the cells in liquid nitrogen until they are needed for experiments.

 

Shipping

Dry ice.

 

Reference

[1] Baker OJ. (2010) “Tight junctions in salivary epithelium.” J Biomed Biotechnol. 2010: 278948. 

[2] Gabbiani G, Rungger-Brandle E. (1981) “The fibroblast.” In Glynn LE, Handbook of Inflammation, Vol. 3: Tissue Repair and Regeneration (pp 1-50). Amsterdam: Elsevier.

[3] Ide F, Shimoyama T, Horie N, Tanaka H. (1999) “Collagenous fibroma (desmoplastic fibroblastoma) presenting as a parotid mass.” J Oral Pathol Med. 28: 465-8.

 

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