重组人MUC-1蛋白
产品名称: 重组人MUC-1蛋白
英文名称: Recombinant Human MUC-1 Protein
产品编号: GMP-TL689
产品价格:
产品产地: China
品牌商标: 同立海源生物
更新时间: 2023-08-25T16:23:17
使用范围: null
规格 | 价格 |
200μg | 4200.0 |
- 联系人 : 崔女士
- 地址 : 北京市大兴区中关村科技园区大兴生物医药产业基地华佗路50号院13号楼
- 邮编 : 100085
- 所在区域 : 北京
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- 邮箱 : cuilimei@seafrom.cn
重组人 MUC-1蛋白(Recombinant Human MUC-1 Protein),GMP级
产品货号:GMP-TL689
产品描述(Description)
Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC-1/CC1/CD227 Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this
protein have been associated with carcinomas. The alpha subunit has cell adhesive properties. MUC-1/CC1/CD227 Can act both as an adhesion and an anti-adhesion protein. This protein May provide a protective layer on epithelial cells against bacterial and enzyme attack.
分子别名(Synonym)
Mucin 1、MUC1、CD227、EMA、H23AG、KL-6、MAM6、MUC-1/SEC、MUC-1/X、MUC1/ZD、PEM、PEMT、PUM、CA 15-3、Episialin
表达宿主(Expression host)
HEK293 细胞
来源(Source)
Human
蛋白序列(Protein Sequence)
DNA 序列编码人 MUC-1(UniProtKB/Swiss-Prot: P15941)表达带有 Fc 标签在 C 末端
分子量(Molecular Weight)
重组人 MUC-1 蛋白包含 366 个氨基酸,预测理论分子量为 38.4 kD
纯度(Purity)
≥95%采用 SDS-PAGE 凝胶和高效液相色谱分析
内毒素(Endotoxin)
<0.1EU/ug
使用说明(Instructions)
稳定性和储存:冻干的样本的可以在4℃保存24个月,溶解后的液体可以于-20℃保存6~12个月,并且避免反复冻融
组成(Component)
含有6%甘露醇的无菌PBS(PH 7.4)的冻干粉
参考文献
1、 Functional variants of TIM-3/HAVCR2 3′UTR in lymphoblastoid cell lines Feifei Pu, Fengxia Chen, Zhicai Zhang, Jing Feng, Ping Xia Future Sci OA. 2018 Jun; 4(5): FSO298. Published online 2018 Mar 15. doi: 10.4155/fsoa-2017-0121
2、Unique Immune Gene Expression Patterns in Bronchoalveolar Lavage and Tumor Adjacent Non-Neoplastic Lung Tissue in Non-Small Cell Lung CancerChih-Hsi Scott Kuo, Chien-Ying Liu, Stelios Pavlidis, Yu-Lun Lo, Yen-Wen Wang, Chih-Hung Chen, How-Wen Ko, Fu-Tsai Chung, Tin-Yu Lin, Tsai-Yu Wang, Kang-Yun Lee, Yi-Ke Guo, Tzu-Hao Wang, Cheng-Ta Yang Front Immunol. 2018; 9: 232. Published online 2018 Feb 12. doi: 10.3389/fimmu.2018.00232
注意:For research and manufacturing use.