FITC标记的神经突触素12抗体
产品名称： FITC标记的神经突触素12抗体
英文名称： Anti-Syntaxin 12/FITC
产品编号： HZ-14443R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Syntaxin 12/FITC Conjugated antibody
FITC标记的神经突触素12抗体
| 英文名称 | Anti-Syntaxin 12/FITC |
| 中文名称 | FITC标记的神经突触素12抗体 |
| 别 名 | MGC51957; Stx12; STX12_HUMAN; STX13; STX14; Syntaxin-12. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 转运蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Syntaxin 12 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Syntaxins, a family of proteins involved in the fusion of synaptic vesicles with the plasma membrane, display broad tissue distribution and contain C-terminal hydrophobic domains that direct them to their respective intracellular compartments. Syntaxin 12, also known as STX12, STX13 or STX14, is a 276 amino acid single-pass membrane protein that contains one t-SNARE coiled-coil homology domain and belongs to the Syntaxin family. Syntaxin 12 regulates protein transport between late endosomes and the trans-Golgi network and interacts with ABC1 (ATP-binding cassette transporter A1), a protein that facilitates cellular release of choline-phospholipids and cholesterol to apoA-I (apolipoprotein A-I). Found in recycling endosomes, Syntaxin 12 colocalizes with transferrin receptor and is encoded by a gene located on human chromosome 1. Function: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. Subcellular Location: Membrane. Golgi apparatus > trans-Golgi network membrane. Similarity: Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain. Database links: Entrez Gene: 100226 Mouse Entrez Gene: 65033 Rat SwissProt: Q9ER00 Mouse Unigene: 28237 Mouse Unigene: 54570 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
突触素是一类参与突触小泡与质膜融合的蛋白质，具有广泛的组织分布，并含有C端疏水结构域，这些结构域将突触小泡引导到各自的细胞内室。Syntaxin 12又称STX12、STX13或STX14，是一种276个氨基酸的单程膜蛋白，含有一个t-SNARE螺旋线圈同源结构域，属于Syntaxin家族。突触素12调节晚期内体与反式高尔基体网络之间的蛋白转运，并与ABC1(ATP结合盒转运体A1)相互作用，ABC1是一种促进胆碱-磷脂和胆固醇向载脂蛋白A-I(载脂蛋白A-I)的细胞释放的蛋白质。发现于循环内切体，Syntaxin 12与转铁蛋白受体共轭，由位于人类染色体1上的基因编码。