FITC标记的三磷酸腺柠檬酸裂解酶抗体
产品名称： FITC标记的三磷酸腺柠檬酸裂解酶抗体
英文名称： Anti-ATP citrate lyase/FITC
产品编号： HZ-3929R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-ATP citrate lyase/FITC Conjugated antibody
FITC标记的三磷酸腺柠檬酸裂解酶抗体
| 英文名称 | Anti-ATP citrate lyase/FITC |
| 中文名称 | FITC标记的三磷酸腺柠檬酸裂解酶抗体 |
| 别 名 | ACL; ATP citrate (pro-S) lyase; ATP citrate synthase; Citrate cleavage enzyme; EC 2.3.3.8; A730098H14RIK; ACLY; ATP CITRATE LYASE; ATPCL; AW538652; Cce; CITRATE LYASE; CLATP; MGC124629. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 122kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ATP citrate lyase |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] Function: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. Subunit: Homotetramer. Subcellular Location: Cytoplasm. Post-translational modifications: ISGylated. Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis. Deacetylated by SIRT2. Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site. Similarity: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. Database links: Entrez Gene: 47 Human Entrez Gene: 104112 Mouse Entrez Gene: 24159 Rat Omim: 108728 Human SwissProt: P53396 Human SwissProt: Q91V92 Mouse SwissProt: P16638 Rat Unigene: 387567 Human Unigene: 282039 Mouse Unigene: 29771 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
ATP柠檬酸裂解酶是许多组织中合成胞浆乙酰基辅酶A的主要酶。该酶是明显相同的亚基的四聚体（相对分子量约440000）。它催化柠檬酸盐和CoA的乙酰辅酶A和草酰乙酸的形成，伴随着ATP水解成ADP和磷酸盐。该产品，acetyl CoA，服务几个重要的生物合成途径，包括脂肪生成和胆固醇生成。在神经组织中，ATP柠檬酸裂解酶可能参与乙酰胆碱的生物合成。已经鉴定了两个编码不同亚型的转录变体。[由RefSeq提供]