Anti-FEN-1 Monoclonal Antibody

品牌：solarbio | 货号：K001442M

商品货号：	商品品牌：	规格	基本售价：	选择规格
K001442M-50ul	solarbio	50ul	960.00元
K001442M-100ul	solarbio	100ul	1600.00元

英文名称	Anti-FEN-1 Monoclonal Antibody
别名	FEN-1;MF1;RAD2
应用	WB IP
稀释比例	WB 1:1000.
交叉反应	Human Mouse Rat
蛋白分子量	45kDa
Gene ID	2237
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG1
免疫原	Purified recombinant human FEN-1 protein fragments expressed in E.coli.
性状	液体
Public Immunogen Range	Purified recombinant human FEN-1 protein fragments expressed in E.coli.
Subcellular Locations	Mitochondrion Nucleus nucleolus nucleoplasm
Swiss Prot	P39748
克隆号	1E7-A6-H6
克隆类型	Monoclonal Antibody
背景资料	The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate,thus passing the substrate from one enzyme to another.The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication.DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene.Therefore,secondary structure can deter the protective function of this protein,leading to site-specific trinucleotide expansions.[provided by RefSeq,Jul 2008]