BCL2L1 monoclonal antibody, clone 2H12
产品名称： BCL2L1 monoclonal antibody, clone 2H12
英文名称： BCL2L1 monoclonal antibody, clone 2H12
产品编号： MAB1802
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against synthetic peptide of BCL2L1.
- Immunogen:
- A synthetic peptide corresponding to amino acids 3-14 of human BCL2L1.
- Host:
- Mouse
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Isotype:
- IgG2a
- Storage Buffer:
- In PBS
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (1-5 ug/mL)
The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Nonionic detergents induce dimerization among members of the Bcl-2 family.
Hsu YT, Youle RJ.J Biol Chem. 1997 May 23;272(21):13829-34.
- 2.
- Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis.
Hsu YT, Wolter KG, Youle RJ.Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3668-72.
- 3.
- bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.
Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G, Thompson CB.Cell. 1993 Aug 27;74(4):597-608.
- Entrez GeneID:
- 598
- Gene Name:
- BCL2L1
- Gene Alias:
- BCL-XL/S,BCL2L,BCLX,Bcl-X,DKFZp781P2092,bcl-xL,bcl-xS
- Gene Description:
- BCL2-like 1
- Omim ID:
- 600039
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq
- Other Designations:
- OTTHUMP00000030550,OTTHUMP00000030551,OTTHUMP00000030553
- Interactome
- Related Disease
- Adenocarcinoma
- Alzheimer Disease
- Amnesia
- Cognition Disorders
- Colorectal Neoplasms
- Disease Progression
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Hematologic Diseases
- Hodgkin Disease
- Lymphoma, B-Cell
- Lymphoma, Follicular
- Lymphoma, Large B-Cell, Diffuse
- Lymphoma, Non-Hodgkin
- Lymphoproliferative Disorders
- Multiple Sclerosis
- Neoplasm Metastasis
- Neuropsychological Tests
- Occupational Diseases