FITC标记的原癌基因酪氨酸蛋白激酶FES抗体
产品名称： FITC标记的原癌基因酪氨酸蛋白激酶FES抗体
英文名称： Anti-FES/FITC
产品编号： HZ-5750R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-FES/FITC Conjugated antibody
FITC标记的原癌基因酪氨酸蛋白激酶FES抗体
| 英文名称 | Anti-FES/FITC |
| 中文名称 | FITC标记的原癌基因酪氨酸蛋白激酶FES抗体 |
| 别 名 | c-fes/fps protein; cFES; feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami; Feline sarcoma oncogene; FPS; Oncogene FES; Oncogene FES feline sarcoma virus; Proto oncogene tyrosine protein kinase Fes/Fps; proto-oncogene tyrosine-protein kinase Fes/Fps. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 90kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FES |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FES is a protooncogene that encodes a protein-tyrosine kinase distinct from c-Src, c-Abl and other nonreceptor tyrosine kinases. FES was originally identified as the cellular homolog of several transforming retroviral oncoproteins. FES plays a role in regulating cytoskeletal rearrangements and inside out signalling that accompany receptor ligand, cell matrix and cell-cell interaction. Genetic analysis using transgenic mouse model implicate FES in the regulation of inflammation and innate immunity. FES modulates the innate immune response of macrophages to LPS challenge, in part, by regulating the internalization and down-regulation of the TLR4 receptor complex. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
FES是一种原癌基因，编码不同于C-Src、C-ABL和其他非受体酪氨酸激酶的蛋白酪氨酸激酶。FES最初被鉴定为几种转化逆转录病毒癌蛋白的细胞同源物。FES在调节伴随受体配体、细胞基质和细胞-细胞相互作用的细胞骨架重排和内向外信号中起作用。利用转基因小鼠模型的遗传分析牵涉到FES在炎症和先天免疫调节中的作用。FES通过调节TLR4受体复合物的内化和下调来调节巨噬细胞对LPS挑战的先天免疫反应。